Welsh Government

Gaining NHS research permission

The Health and Care Research Wales Permissions Service helps you obtain NHS permission in Wales. The Service coordinates a streamlined and consistent process on behalf of NHS Wales.

For research carried out in NHS Wales, NHS organisations must give their permission before the research starts. The Permissions Service accepts all applications for NHS research in Wales.

Who can use the Permissions Service?

Anyone who wants to open a research study in NHS Wales can use the service. 

Are you using Participant Identification Centres?

Application guides

IRAS guidance

What about UK-wide studies?

We work with the national coordinating functions of England, Northern Ireland and Scotland to make sure the flow of research study information allows efficient processing of UK-wide studies. For more information, contact us: Research-permissions@wales.nhs.uk

What happens once I submit my NHS research permission application?

For a Wales led study, the Service will:

  • Confirm the NHS R&D Form application is complete, including supporting documents
  • Carry out the study-wide governance review
  • Share the application with participating nations
  • When a NHS Site Specific Information (SSI) Form application is received for a NHS organisation in Wales we will inform the NHS organisation’s R&D office

The NHS R&D office will:

  • Confirm the NHS SSI Form application is complete, including supporting documents
  • Carry out the local governance review
  • Decide if they are granting permission for your study
  • Notify you of their decision

NHS Research Study amendments

Amendments are changes made to a research study after the necessary permissions and approvals have been obtained. NHS R&D offices need to be notified of amendments.

What happens once I submit my NHS Research Study amendment application?

For a Wales led study, the Service will:

  • Confirm the application is complete, including supporting documents
  • Categorise the amendment and calculate the appropriate implementation date
  • Share the amendment with participating nations
  • Inform the participating NHS organisation’s R&D office

The NHS R&D office will:

  • Assess the impact of the amendment
  • Decide if they can support the amendment
  • Put in place necessary support arrangements
  • Notify you of their decision