Welsh Government

COVID-19 research in Wales

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The following Coronavirus COVID-19 related research studies are active or are in set up in Wales: 

Open and recruiting – Urgent Public Health (UPH) studies

Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial

The Randomised Evaluation of COVID Therapy (RECOVERY) trial will test if existing or new drugs can help patients hospitalised with confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board, Velindre University NHS Trust


COVID-19: ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) / CCP-UK Clinical Characterisation Protocol for Severe Emerging Infection

The researchers will collect samples and data from COVID-19 patients in the UK to answer many urgent questions about the virus in real time.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


Coronavirus infection in immunosuppressed children

This study is designed to allow families of immunosuppressed children and young people to self-record their experiences of COVID-19 and other viral respiratory illnesses during the COVID-19 epidemic. 

Health and Care Research Wales specialty lead Dr Phil Connor identified colleagues across Wales who are now referring patients to this study.

Open in: Aneurin Bevan University Health Board, Cardiff and Vale University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board. 


REMAP-CAP: a platform trial for severely ill patients with COVID-19

A randomised controlled trial for patients admitted to the intensive care unit (ICU) with severe Community-Acquired Pneumonia (CAP). This trial studies a number of different treatment categories under one platform with an aim to determine the best package of treatment for patients.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Swansea Bay University Health Board

In set up: Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board


Pandemic Respiratory Infection Emergency System Triage (PRIEST) study

Pandemic Respiratory Infection Emergency System Triage (previously: The PAINTED study: Pandemic Influenza Triage in the Emergency Department).

Open in: Aneurin Bevan University Health Board


UK Obstetric Surveillance System (UKOSS)

Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy.

Open in: all Health Boards in Wales


Evaluation and refinement of pandemic influenza community assessment tools (FLU-CATs)

Real time refinement and validation of criteria and tools used in primary care to aid hospital referral decisions for patients of all ages in the event of surge during an influenza pandemic.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Powys Teaching Health Board, Swansea Bay University Health Board


Genetics of susceptibility and mortality in critical care (GenOMICC)

Our genes determine how susceptible we are to life-threatening infection. When a patient is already sick, different genetic factors determine how likely they are to survive. The GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) study will identify the specific genes that cause some people to be susceptible to specific infections and consequences of severe injury.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


RECOVERY - Respiratory Support

This study is aiming to determine if continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) is clinically effective compared to standard care (excluding CPAP or HFNO).

Open in: Aneurin Bevan University Health Board

In set up: Cwm Taf Morgannwg University Health Board


Neonatal Complications of Coronavirus Disease (COVID-19) Study

This is a national surveillance programme using the standard British Paediatric Surveillance Unit (BPSU) approach. This study will run alongside and be cross-linked with the maternal surveillance study run through the United Kingdom Obstetric Surveillance System (UKOSS; CPMS: 14162), which is already in progress.

Open in: all Health Boards in Wales


Pregnancy and Neonatal Outcomes in COVID-19

To better understand some specific research questions as to how COVID-19 affects early pregnancy, fetal growth, prematurity and virus transmission to the baby the researchers will construct a registry of women with suspected and confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Swansea Bay University Health Board

In set up: Hywel Dda University Health Board


ACCORD-2: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients

Open in: Aneurin Bevan University Health Board

In set up: Swansea Bay University Health Board


Investigating a Vaccine Against COVID-19 (COV002)

A phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19. This study will enable us to assess how well people of all ages can be protected from COVID-19 with this new vaccine called ChAdOx1 nCoV-19. It will also give us valuable information on safety aspects of the vaccine and its ability to generate good immune responses against the virus. In total we will enrol up to 5260 volunteers.

Open in: Aneurin Bevan University Health Board, Public Health Wales


Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE)

The trial aims to give a rapid answer about the effectiveness of hydroxychloroquine in modifying the disease course of COVID-19.

Open: Wales wide


Phase 3 multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of canakinumab on cytokine release syndrome in patients with COVID-19-induced pneumonia (CAN-COVID)

Open in: Cardiff and Vale University Health Board


Multiarm Therapeutic study in pre-ICU patients admitted with COVID-19 - Repurposed Drugs (TACTIC-R)

TACTIC is recruiting patients at an early stage of COVID-19 disease course, aiming for a time point where the patient is experiencing infective symptoms and starting to show pulmonary complications. The purpose is to prevent organ damage and reduce the need to transfer to ICU and ventilation. The aim of this trial is to reduce the number of COVID-19 patients that will be admitted to ICU.

Open in: Cardiff and Vale University Health Board


The effectiveness and cost-effectiveness of a group programme for men who are concerned about their abusive behaviour in relationships with women: A randomised controlled trial (REPROVIDE)

This study has been open to recruitment since October 2019, and forms part of an NIHR programme grant called 'Reaching Everyone: Programme of Research on Violence in Diverse Domestic Environments' (REPROVIDE). It has been repurposed in light of COVID-19 as the victim support and signposting services to partners and ex-partners, and the identification and monitoring of abusive men that are provided within the context of the study are vitally important services to continue.

Open: Wales wide


Urgent Public Health Studies in set up

CATALYST: A randomised phase II proof of principle multi-arm multi-stage trial designed to guide the selection of interventions for phase III trials in hospitalised patients with COVID-19 infection

This is a clinical trial where participants will be randomly allocated to one of several possible new treatments for COVID-19.

In set up: Swansea Bay University Health Board


STOP-COVID19

This clinical trial is designed to evaluate the potential of Brensocatib (INS1007) as a novel host directed therapy for the treatment of adult patients hospitalized with COVID-19. 

In set up: Cardiff and Vale University Health Board


Other COVID-19 studies

CARA study

This study will recruit UK ambulance staff to complete a short online questionnaire assessing their current perceived preparedness and wellbeing during the current accelerative phase of COVID-19 outbreak

Open in: Welsh Ambulance Service NHS Trust


COVID-19 Emergency Response Assessment (CERA)

The study aims to assess the health outcomes of those front line doctors dealing with the COVID-19 outbreak. It will focus on doctors working in high impact areas, the emergency department, anaesthesia and intensive care medicine.

Open in: Swansea Bay University Health Board

In set up: Aneurin Bevan University Health Board, Cwm Taf Morgannwg University Health Board 


CovidSurg

Outcomes of Surgery in COVID-19 infection: international cohort study (COVIDSurg)

Open in: Aneurin Bevan University Health Board, Cardiff and Vale University Health Board


PECC-19

Paramedic Experiences of providing Care during the 2020 COVID-19 Pandemic (PECC-19): A qualitative study using Grounded Theory

Open in: Welsh Ambulance Services NHS Trust


COVER: COvid-19 Vascular sERvice Study

Determining the impact of COVID-19 pandemic on the provision, practice and outcomes of vascular surgery

The COVER study will be a multi-centre prospective project of the modifications to the vascular service, condition management and outcomes of interventions during the COVID-19 pandemic.

Open in: Aneurin Bevan University Health Board


PHIND study

Clinical Evaluation of a Point of Care (POC) assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome

Open in: Aneurin Bevan University Health Board


PROLIFIC Trial (COVID-19) ChemoPROphyLaxIs For covId-19 infeCtious disease

Frontline NHS staff with direct patient contact have the highest likelihood of exposure to SARS-CoV-2 and development of COVID-19 disease. Efforts to protect these workers from development of COVID-19, using drugs to prevent the disease, require urgent evaluation. Eligible participants will be frontline NHS workers aged 18 to 70 years who work in a healthcare setting with direct patient care. 

Open in: Cardiff and Vale University Health Board


The CTEX WG5 (COVID-19 CPAP) MULTI SITE DEVICE INVESTIGATION

Open in: Aneurin Bevan University Health Board, Hywel Dda University Health Board


Characterising the immune response in COVID-19

This research will look at the immune system response in a range of hospitalised COVID-19 patients and in biobanked samples using very advanced blood analysis not normally available in hospital settings. We hope to identify patterns of immune response in people with COVID-19 at different stages / severity of illness.

Open in: Hywel Dda University Health Board


COVID-19 & Stress Study

The aim of our research is to (i) understand the magnitude and nature of the psychological harm inflicted by the pandemic; (ii) examine the potential for it to translate into physical harm; and (iii) provide evidence to inform how these harms may be mitigated.

Open in: Cwm Taf Morgannwg University Health Board


Co-VIDA: A digital wellbeing tool to assess the psychological impact of the COVID-19 pandemic on NHS healthcare professionals

Evidence suggests worsening of mental health in health workers reduces quality of care they provide and also promotes absenteeism or even resignations. Changes in mental health wellbeing during pandemics may be linked to specific risk or protective factors – and there is intrinsic value in understanding these. Recent work from China on health workers revealed elevated anxiety, depression, insomnia and trauma – however given the key differences in Chinese and UK health systems, and shortfalls in that study suggest new research should urgently be done in the UK to understand the impact of COVID on NHS and non-NHS health workers.

Open in: Swansea Bay University Health Board


Long and short term effects of standard of care treatments for people with cancer

Immune checkpoint inhibitors (ICPI) are drugs that release cancer immunity. ICPI cause immune attack on normal organs resulting in immune related adverse events (IrAE) including bowel inflammation called immune related colitis (IR-colitis). We will describe the clinical and pathological features of IR-colitis, exploring a role for viruses including Epstein Barr virus (EBV) which lives harmlessly in most people. More broadly, the study will explore clinical, pathological and microbiological features associated with ICPI treatment, cancer control and IrAE.

Open in: Cwm Taf Morgannwg University Health Board


Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection

Open in: Cardiff and Vale University Health Board


National COVID-19 Chest Imaging Database (NCCID) v1.0

NCCID aims to establish a national research database for all UK NHS Trusts to provide chest X-ray and CT images and associated clinical data for patients suspected of Covid-19 infection. 

Open in: Cwm Taf Morgannwg University Health Board


PACE

The main aims of this study are to record how many of these patients have had COVID-19 previously, have an active infection or go on to develop COVID-19 whilst receiving treatment for their Acute Myeloid Leukaemia (AML).

Open in: Cardiff and Vale University Health Board


ATOMIC2

The ATOMIC2 study is investigating if a common antibiotic called Azithromycin (AZM) may prevent the patients from getting worse

Open in: Cardiff and Vale University Health Board


A prospective non interventional study to evaluate the role of immune and inflammatory response in recipients of allogeneic haematopoietic stem cell transplantation (SCT) affected by severe COVID19 infection

The aim of the present study is to study the immunology/inflammatory response of patients who present with a severe COVID19 related disease after having received stem cell transplantation. 

Open in: Cardiff and Vale University Health Board


Coagulopathy associated with Covid 19 (CA-Covid19) A Multi-Centre observational study

In this retrospective-prospective: multicentre study, we will document the patient characteristics, presenting haematological parameters and associated comorbidities and their association with bleeding, thrombosis and mortality in patients admitted for hospital treatment. Determining the predictive value of patient characteristics and presenting laboratory measurements for clinical outcomes in these patients will allow us to optimise management of these patients in the future. 

Open in: Cardiff and Vale University Health Board


Characterisation of the Immune Response to SARS-CoV-2 Infection

To study how the virus SARS-CoV-2, more commonly called Coronavirus, affects the part of the body that fights infection, the immune system. This study will look at how the immune system responds to the virus and how it varies from person to person.

Open in: Cwm Taf Morgannwg University Health Board


COVID-19, employment and health in Wales

This study aims to determine:
(1) The underlying prevalence of precarious employment in Wales;
(2) The impact of precarious employment on individual and household health and wellbeing;
(3) The impact of COVID-19 on employment security,
(4) The impact of changes to employment on individual and household health;
(5) The public perceptions of fair work

Open in: Public Health Wales


COPE Study: COVID-19 in Older People

The study aim is to assess frailty and multi-morbidity in older patients admitted to hospital with a diagnosis of COVID -19. Also to correlate frailty with both short term and long-term outcomes. 

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board


BREATHE: B cell Receptor Evaluation for Antibodies to proTect Human Exposure to SARS-COV-2

PROJECT BREATHE aims to bring together a coalition of companies, academics, NHS and public sector across the UK and internationally to generate large numbers of doses of therapeutic antibodies against COVID19. In order to be successful, we need to source samples from patients with a range of responses to viral infection.

Open in: Cardiff and Vale University Health Board


CovPall: palliative care for those with COVID-19 (v1.0)

This research aims to rapidly evaluate the palliative care response in COVID-19 to improve care now and in the future.

Open in: Cardiff and Vale University Health Board


Rapid-19: Rapid diagnostics, antibody testing and host response in children with COVID-19 

The aims of this projects are to (i) validate the performance of a rapid molecular test for detecting SARS-CoV-2 in children (ii) follow healthy children through the seroconversion process to better understand the signs and symptoms of Covid-19 (iii) understand the immune response in children with severe disease.

Open in: Cardiff and Vale University Health Board